Laboratory of Optical Bioimaging and Spectroscopy

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Deep Tissue Imaging Platform

​We are developing and applying novel deep tissue imaging platforms including:

Isotope probed multiplex stimulated Raman scattering (ipm-SRS),

Multiphoton fluorescence (MPF),

Enhanced stimulated Raman scattering (ESRS) microscopy.


Drug Delivery

We use bioorthogonally-labeled SRS combined with multiphoton fluorescence microscopy to image drug delivery in animals.


Two photon fluorescence imaging of brain microvessel ( Red is solutes injection into vessels) and astroctyes (Gcamp 6 ) in vivo in rodent,

Metabolism

We use label free and bioorthogonally-labeled SRS combined with multiphoton fluorescence microscopy to detect early stage in situ metabolic changes in aging, obesity, development, neurodegenerative diseases, cancer, and more.