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"Prof. Lingyan Shi and her team are developing and applying new ultrafast laser scanning multimodal imaging and spectroscopic technologies, such as stimulated Raman scattering (SRS), DO-SRS, second harmonic generation (SHG), Fluorescence Lifetime Imaigng (FLIM), and multiphoton fluorescence (MPF) microscopy, for visualizing molecular events and metabolic dynamics in situ at subcellular resolution for studying aging and diseases.
"Prof. Lingyan Shi and her team are developing and applying new ultrafast laser scanning multimodal imaging and spectroscopic technologies, such as stimulated Raman scattering (SRS), DO-SRS, second harmonic generation (SHG), Fluorescence Lifetime Imaigng (FLIM), and multiphoton fluorescence (MPF) microscopy, for visualizing molecular events and metabolic dynamics in situ at subcellular resolution for studying aging and diseases.
Shi and her team discovered "Golden Window" (from 1550nm to 1870nm) wavelength for deep optical tissue imaging (Shi et al., 2016), established PRM (Zhang et al., 2024) SRS and A-POD (Jang et al., 2023) super resolution multi-molecular imaging platform. Shi Lab is developing and applying bioorthogonal SRS imaging methods for dissecting complex cellular machinery in living organisms during aging processes and disease progression, offering powerful tools potentially for diagnosis, assessing therapeutic efficacy/resistance, as well as for mechanistic understanding of scientific fundamentals in neurodegenerative diseases, cancer, drug discovery, and aging processes."
Shi and her team discovered "Golden Window" (from 1550nm to 1870nm) wavelength for deep optical tissue imaging (Shi et al., 2016), established PRM (Zhang et al., 2024) SRS and A-POD (Jang et al., 2023) super resolution multi-molecular imaging platform. Shi Lab is developing and applying bioorthogonal SRS imaging methods for dissecting complex cellular machinery in living organisms during aging processes and disease progression, offering powerful tools potentially for diagnosis, assessing therapeutic efficacy/resistance, as well as for mechanistic understanding of scientific fundamentals in neurodegenerative diseases, cancer, drug discovery, and aging processes."
Newly synthesized proteins, lipids, and DNA in a dividing cell.
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