Peer-reviewed Journal Publications

UCSD: 

2025

96. Yang H, Xun J, Li Y, Mondal A, Lv B, Watkins S, Shi L, Tan JX et al. ,LYVAC/PDZD8 is a lysosomal vacuolator.DOI:10.1126/science.adz0972  Science 389, eadz0972 (2025).

95. Menozzi L*, Li Z*, Choi S, Vu T, Shi L**, and Yao J**, "Light and metabolism: label-free optical imaging of metabolic activities in biological systems [Invited]," https://doi.org/10.1364/BOE.572304 Biomed. Opt. Express 16, 3770-3796 (2025).

94.  (Preprint) Gorman BL, Li Z, Deutsch G, Huyck HL, Beishembieva N, Olson H, Villazon J, Yu P, Pryhuber GS, Clair G, Shi L**, Anderton CR**, "A multimodal imaging approach for imaging the metabolic changes resulting from bronchopulmonary dysplasia", 06.16.660017; doi: https://doi.org/10.1101/2025.06.16.660017 bioRxiv 2025.

93. Fung AA, Li Z, Boote C, Markov P, Gaut JP, Jain S** & Shi L**, "Label-free multimodal optical biopsy reveals biomolecular and morphological features of diabetic kidney tissue in 2D and 3D". https://doi.org/10.1038/s41467-025-59163-w  Nat Commun 16, 4509 (2025).

92. Shi L** & Rodríguez-Contreras A**, "Paradoxical effect of the volatile anesthetic isoflurane on calcium activity of cortical vascular endothelial cells in vivo", https://doi.org/10.1117/1.NPh.12.2.025015,  Neurophotonics, 2025.

91. Villazon J., Li Z., Fan A., Shi L**," Multimodal Optical Imaging Platform for Studying Cellular Metabolism". J. Vis. Exp. (220), e67906, doi:10.3791/67906 (2025).

90. Hoang K, Prayotamornkul S, Kuo C, Jang H, Shi L**, "Optical imaging of metabolic dynamics in ALS under methionine regulation," https://doi.org/10.1117/1.JBO.30.S2.S23906 J. Biomed. Opt. 30(S2) S23906 (24 May 2025).

89.  Qian N, Zhao Z, Khoury EE, Gao X, Canela C, Shen Y, Shi L, Shi L, Hu F, Wei L & Min W, "Illuminating life processes by vibrational probes". https://doi.org/10.1038/s41592-025-02689-0 Nat Methods 22, 928–944 (2025).

88. Zhao GJ, Han S.Y,Li Y Yuan D,Qin S,Li Y,Jang H, Chen L,Wei T.W,He M, Li Y, Bouman Chen Z, Shi L, Chien S,& Shyy J.Y,  "METTL3 mediates atheroprone flow–induced glycolysis in endothelial cells"doi.org/10.1038/s41592-025-02689-0 , https://doi.org/10.1073/pnas.2424796122 Proc. Natl. Acad. Sci. U.S.A. 122 (19) e2424796122, (2025).

87. Frei MS, Sanchez SA, He X, Liu L, Schneider F, Wang Z, Hakozaki H, Li Y, Lyons A, Rohm T, Olefsky J, Shi L, Schöneberg J, Fraser S, Mehta S, Wang Y & Zhang J,  "Far-red chemigenetic kinase biosensors enable multiplexed and super-resolved imaging of signaling networks". https://doi.org/10.1038/s41587-025-02642-8 Nat Biotechnol (2025). 

86. Villazon J, Dela Cruz N, and Shi L**, "Cancer Cell Line Classification Using Raman Spectroscopy of Cancer-Derived Exosomes and Machine Learning", DOI: 10.1021/acs.analchem.4c06966, Analytical Chemistry 2025

85. Shi, L**., Villazon, J. "Optical imaging unveiling metabolic dynamics in cells and organisms during aging and diseases". https://doi.org/10.1007/s44258-024-00049-9 Med-X 3, 8 (2025).

84. Unfried M, Schmauck-Medina T, Amin ND, S. Boyden E, Fuellen G, Han J, Hanna J, Heckenbach I, Khodosevich K, Melton L, Moeendarbary E, Moon T, Peleg S, Sandberg A, Shi L, Bakula D, Zhavoronkov A & Scheibye-Knudsen M,  "Innovations in aging biology: highlights from the ARDD emerging science & technologies workshop", https://doi.org/10.1038/s41514-025-00193-5 npj Aging 11, 8 (2025). 

83.Fan A*, Alvarado E*, Block A*, Shi L**, A  Mini Review of Quantitative Optical Technologies for Imaging Cell and Tissue Metabolism, https://doi.org/10.1016/j.cobme.2025.100581  Current Opinion in Biomedical Engineering. 2025.

2024

82. Jang H, Wu S, Li Y, Li Z, Shi L**, "Metabolic nanoscopy enhanced by experimental and computational approaches. https://doi.org/10.1038/s44303-024-00062-y npj Imaging 2, 55 (2024).

81. Li Z, Sarikhani E, Prayotamornkul S, Pushpa Meganathan D, Jahed Z**, and Shi L**, "Multimodal Imaging Unveils the Impact of Nanotopography on Cellular Metabolic Activities", DOI: 10.1021/cbmi.4c00051 Chemical & Biomedical Imaging, 2024.

80. (Preprint) Li Y*, Zhang Z*, Enninful A*, Nam J, Qin X, Villazon J, Fazard N, Fung AA, Xu ML, Jang H, Zhang N, Fan R**, Ma Z**, Shi L**, "All-Optical Multimodal Mapping of Single Cell Type-Specific Metabolic Activities via REDCAT", 11.07.622511; https://www.biorxiv.org/content/10.1101/2024.11.07.622511v1 bioRxiv 2024.

79.(Preprint) Fung AA, Li Z, Boote C, Markov P, Jain S**, Shi L**, "Label-Free Optical Biopsy Reveals Biomolecular and Morphological Features of Diabetic Kidney Tissue in 2D and 3D" 10.27.620507; doi: https://doi.org/10.1101/2024.10.27.620507 bioRxiv 2024.

78. Villazon J, Jang H, and Shi L**, "Nonlinear Optical Imaging Modalities in Biomedicine", 3:5, 290-298, https://doi.org/10.1089/genbio.2024.0039 2024 GEN Biotechnology 2024, (Journal Cover).

77. E. Sarikhani, V. Patel, Z. Li, D. P. Meganathan, K. Rahmani, L. Sadr, R. Hosseini, D. Visda, S. Shukla, H. Naghsh-Nilchi, A. Balaji, G. McMahon, S. Chen, J. Schöneberg, C. A. McHugh, L. Shi, Z. Jahed, "Engineered Nanotopographies Induce Transient Openings in the Nuclear Membrane". 2410035. https://doi.org/10.1002/adfm.202410035 Adv. Funct. Mater. 2024, (Journal Cover).

76. Li Y, Munoz-Mayorga D, Nie Y, Kang N, Tao Y, Lagerwall J, Pernaci C, Curtin G, Coufal NG, Mertens J, Shi L**, Chen X**, "Neuronal AMPK regulates microglial lipid droplet accumulation in tauopathy brain", https://doi.org/10.1016/j.cmet.2024.03.014  Cell Metabolism, 2024.

75. Zhang W+, Li Y+, Fung AA+, Li Z, Jang H, Zha H, Chen X,  Gao F, Wu JY, Sheng H, Yao J, Skowronska-Krawczyk D, Jain S, & Shi L** ,"Multi-molecular hyperspectral PRM-SRS microscopy", https://doi.org/10.1038/s41467-024-45576-6, Nature Communications15, 1599. 2024.

74. H. J. Meyer, S. Mamani, Z. Li, L. Shi, R. R. Alfano, "Femtosecond optical Kerr effect in normal and grades of cancerous breast tissues as a new optical biopsy method", 17(2), e202300344. https://doi.org/10.1002/jbio.202300344 J. Biophotonics 2024.

73. Yao R, DiSpirito A, Jang H, McGarraugh CT, Nguyen VT, Shi L, Yao J, "Virtual‐point‐based deconvolution for optical‐resolution photoacoustic microscopy", 17(8), e202400078. https://doi.org/10.1002/jbio.202400078 J. Biophotonics 2024.

72. Leineweber W, Rowell M, Ranamukhaarachchi S,  Walker A, Li Y, Villazon J, Mestre-Farrera A, Hu Z, Yang J, Shi L, Fraley S,  "Divergent iron regulatory states contribute to heterogeneity in breast cancer aggressiveness", iScience, Volume 27, Issue 9, 110661, https://doi.org/10.1016/j.isci.2024.110661 , 2024

71. Jang H , Li Y , Wu S , Shi L**. “Super-resolution stimulated Raman scattering microscopy with GUI supported APoD”, DOI: 10.1002/CPZ1.970, Current Protocols, 2024

2023

70. Song Q*, Li Y*, Jin Z, Liu H, Creyer M, Yim W, Huang Y, Hu X, He T, Li Y, Kelley S, Shi L, Zhou J**, and Jokerst J**, "Self-Assembled Homopolymeric Spherulites from Small Molecules in Solution", JACS, DOI: 10.1021/jacs.3c08356, 2023

69.Li Z, Nguyen C, Jang H, Hoang D, Min S, Ackerstaff E, Koutcher J, Shi L** "Multimodal Imaging of Metabolic Activities for Distinguishing Subtypes of Breast Cancer", Biomedical Optics Express,Vol. 14, Issue 11, pp. 5764-5780, https://doi.org/10.1364/BOE.500252, 2023

68. Yim W, Retout M, Chen A, Ling C, Amer L, Jin Z, Chang Y, Chavez S, Barrios K, Lam B, Li Z, Zhou J, Shi L, Pascal T, and Jokerst J**, "Goldilocks Energy Minimum: Peptide-Based Reversible Aggregation and Biosensing", ACS Appl. Mater. Interfaces 2023, 15, 36, 42293–42303, https://doi.org/10.1021/acsami.3c09627, 2023

67. Shi L**, Li Y, Li Z, "Early cancer detection by SERS spectroscopy and machine learning", Light: Science & Applications https://www.nature.com/lsa news & views, https://doi.org/10.1038/s41377-023-01271-7 , 2023

66.  Li Y, Chang P, Sankaran S, Jang H, Nie Y, Zeng A, Hussain S, Wu JY, Chen X, Shi L**, "Bioorthogonal SRS Imaging Uncovers Lipid Metabolic Dynamics in Brain During Aging" GEN Biotechnology, https://doi.org/10.1089/genbio.2023.0017 , 2023

65. Shi L**, Jang H, "Perspectives on SRS Imaging of Nanoparticles", Accounts of Materials Research,2023, 4, 9, 726–728 https://pubs.acs.org/doi/10.1021/accountsmr.3c00100 , 2023  (Journal Cover)

64. Bagheri, P., Hoang, K., Kuo, C. y., Trivedi, H., Jang, H. , Shi L.**, "Bioorthogonal Chemical Imaging of Cell Metabolism Regulated by Aromatic Amino Acids", e65121,J. Vis. Exp.,(2023)

63. Jang H, Li Y,  Fung AA, Bagheri P, Hoang K,  Skowronska-Krawczyk D, Chen X, Wu JY,  Bintu B,  Shi L**, "Super-resolution stimulated Raman Scattering microscopy with A-PoD",, https://doi.org/10.1038/s41592-023-01779-1 Nature Methods 2023.

62. Jang H, Shi L**, "A deconvolution algorithm to achieve super-resolution stimulated Raman scattering imaging". https://doi.org/10.1038/s41592-023-01780-8 Nat Methods (2023).

2022

61. E. J. Galvez, B. Sharma, F. K. Williams, C.-J. You, B. Khajavi, J. Castrillon, L. Shi, S. Mamani, L. A. Sordillo, L. Zhang, and R. R. Alfano, "Decoherence of photon entanglement by transmission through brain tissue with Alzheimer’s disease," , https://doi.org/10.1364/BOE.474469 Biomed. Opt. Express 13, 6621-6630 (2022).

60. Zhang W, Li Y,  Fung AA, Li Z, Jang H, Zha H, Chen X, Gao F,  Wu JY,  Sheng H,  Yao J,  Skowronska-Krawczyk D,  Jain S,  Shi L**, "Multi-Molecular Hyperspectral PRM-SRS Imaging", https://doi.org/10.1101/2022.07.25.501472 biorxiv, 2022.

59. Preprint (Biorxiv): Shi L**, Rodriguez-Contreras A, "The general anesthetic isoflurane inhibits calcium activity in cerebrovascular endothelial cells and disrupts vascular tone", doi: https://doi.org/10.1101/2022.03.25.485881, biorxiv 2022.

58. Mamani S, Shintre S, Li Z, Rodríguez-Contreras A, Shi L**,  Alfano R**, "OAM transmission of polarized multipole laser beams in rat cerebellum tissue", https://doi.org/10.1016/j.optcom.2022.129241 Optics Communications 532, 129241, 2023.

57. Liu X, Shi L, Shi L, Wei M, Zhao Z, Min W,  "Towards Mapping Mouse Metabolic Tissue Atlas by Mid-Infrared Imaging with Heavy Water Labeling" https://doi.org/10.1002/advs.202105437  Advanced Science, Mar 2022.

56. Li Y., Zhang W., Fung A.A., Shi L.**,  "DO-SRS Imaging of Diet Regulated Metabolic Activities in Drosophila During Aging Processes", http://doi.org/10.1111/acel.13586, Aging Cell. 2022;00:e13586. 2022.

55. Li Z., Mazhar S.F.B.,Alfano R., Shi L.**,  "The 1086 cm-1 Phonon Decay Routes in the O- and E-directions in Calcite from Raman Scattering", https://doi.org/10.1016/j.ijleo.2022.168901, Optik, 2022.

54. Agrawal R., Larrea D., Xu Y., Shi L., Zirpoli H., Cummins L., Emmanuele V., Song D.,Yun T., Macaluso F., Min W., Kernie G., Deckelbaum R., Area-Gomez E., “Alzheimer’s-associated upregulation of mitochondria-associated ER membranes after traumatic brain injury”, https://link.springer.com/article/10.1007/s10571-022-01299-0, Cellular & Molecular Neurobiology 2022. 

53. Fung A.A., Hoang K., Zha H., Chen D., Zhang W., and Shi L.**  "Imaging Sub-Cellular Methionine and Insulin Interplay in Triple Negative Breast Cancer Lipid Droplet Metabolism", https://doi.org/10.3389/fonc.2022.858017 Frontier Oncology, Cancer Metabolism , 2022.

52. Zhang Z, Tang R, Chen X, Waller L, Kau A, Fung A.A., Gutierrez B, An C, Cho S, Shi L, Lo Y. "A high-throughput technique to map cell images to cell positions using a 3D imaging flow cytometer", 119 (8) e2118068119; https://doi.org/10.1073/pnas.211806811 PNAS, Feb 2022.

51. Zhang W*, Craddock T**, Li Y, Swartzlander M, Alfano R, Shi L**  "Fano Resonance in Raman Spectra of Tubulin and Microtubules Reveals Active Quantum Effects", (Cellpress publisher), Volume 2, Issue 1, 100043, 2022, https://doi.org/10.1016/j.bpr.2021.100043  Biophysical Reports 2022.

2021 (** corresponding author; * equal contribution author)

50.  Li Y., Bagheri P, Chang P, Zeng A, Hao J, Fung A.A., Wu J and Shi L**, “Direct Imaging of Lipid Metabolic Changes in Drosophila Ovary during Aging using DO-SRS Microscopy”,  Frontiers in Aging-Aging, https://doi.org/10.3389/fragi.2021.819903 Metabolism and Redox Biology, 2021.

49.  Bagheri P*., Hoang K*., Fung A.A., Hussain S., Shi L.**, "Visualizing Cancer Cell Metabolic Dynamics Regulated with Aromatic Amino Acids using DO-SRS and 2PEF microscopy", https://doi.org/10.3389/fmolb.2021.779702, Front. Mol. Biosci. 2021.

48.  Li Y, Zhang W, Fung AA., Shi L.**, "DO-SRS Imaging of Metabolic Dynamics in Aging Drosophila", https://doi.org/10.1039/D1AN01638E , Analyst. 2021.

47. Alfano R,  Mazhar SFB, Sharonov M, L Shi, "Ultra-supercontinuum generation with high intense femtosecond pulses ", Optik, 168208, 2021.

46. Alfano R, Mazhar SFB, Shi L, "Higher harmonic and supercontinuum generation arising from electronic self-phase modulation under ultrafast laser pulses for various states of matter", Optik, 167872, 2021.

45. Shi L, Wei M, Miao Y, Qian N, Shi L, Singer R, Benninger R, Min W., “One-shot highly-multiplexed volumetric mapping with Raman dye imaging and tissue clearing”, https://doi.org/10.1038/s41587-021-01041-z,Nature Biotechnology. 2021.

44. Chang, D.; Brown, Q.; Tsui, G.; He, Y.; Liu, J.; Shi, L.**; Rodríguez-Contreras, A**. Distinct Cellular Profiles of Hif1a and Vegf mRNA Localization in Microglia, Astrocytes and Neurons during a Period of Vascular Maturation in the Auditory Brainstem of Neonate Rats. 11, 944. https://doi.org/10.3390/brainsci11070944 2020 Brain Sci. 2021.

43. Shi L.**, Fung A.A. Andy Zhou. “Advances of Stimulated Raman Scattering Imaging in Tissues and Animals”, Quantitative Imaging in Medicine and Surgery. Vol 11, No 3, 2021. 

2020

42.  Fung A. A., Shi L**. “Mammalian cell and tissue imaging using Raman and coherent Raman microscopy”. 2020;e1501. https://doi.org/10.1002/wsbm.1501 , WIREs Systems Biology and Medicine. 2020.

41.  Shi L.**, Gayen T., Budansky Y., Yoo K., Secor J., Harvey T., Harvey G., Shumyatsky P., Nolan D., and Alfano R. "Enhanced stimulated raman scattering of solvent due to anharmonic energy transfer from resonance raman solute molecules". Opt. Express 28, 21792-21804, 2020.

40.  Shi L., Liu X.*, Shi L.*, Stinson H., Rowlette J., Kahl L., Evans C., Zheng C., Dietrich L., Min W. "Mid-infrared metabolic imaging with vibrational probes". Nature Methods 17, 844-851, 2020.

39. Mazhar SFB., Meyer H.J., Samuels T., Sharonov M., Shi L, Alfano R.R. “Explanation of the competition between O-and E-wave induced stimulated Raman and supercontinuum in calcite under ultrafast laser excitation”. Applied Optics 59 (17), 5252-5257, 2020.

38.  Xiong H., Qian N., Zhao L., Shi L, Miao Y, Min W. “Background-free imaging of chemical bonds by a simple and robust frequency-modulated stimulated Raman scattering microscopy”. Optics Express 28 (10), 15663-15677, 2020.

37.  Bendau E., Smith J., Zhang L., Ackerstaff E., Kruchevsky N., Wu B., Koutcher J. A., Alfano R. R. and Shi L.** “Distinguishing Metastatic Triple Negative Breast Cancer from Non‐Metastatic Breast Cancer using SHG Imaging and Resonance Raman Spectroscopy". J. Biophotonics, 2020;e202000005, 2020. 

36.  Mamani S., Nolan D. A., Shi L., Alfano R. R. “Special classes of optical vector vortex beams are Majorana-like photons”. Optics Communications, 464, 125425, 2020. 

35.  Shumyatsky P., Shi L., Sordillo L. A., Budansky Y., Alfano R. R. “Comparison of continuous wave versus picosecond SRS and the resonance SRS effect”. Applied Optics 59 (3), 622-627, 2020.

Before UCSD:

2019

34.  Zhang L*, Shi L*, Shen Y*, Miao Y, Wei M, Qian N, Liu Y, Min W. “Spectral tracing of deuterium for imaging glucose metabolism”. Nature Biomedical Engineering 3(5):402-413, 2019. (co-first author)

33.  Wei M*, Shi L*, Shen Y, Zhao Z, Guzman A, Kaufman L, Wei L, Min W. “Volumetric chemical imaging by clearing-enhanced stimulated Raman scattering microscopy”. PNAS 116 (14): 6608-6617, 2019. (co-first author)

32.  Zhou Y., Liu C., Wu B.,Yu X., Cheng G., Zhu K., Wang K., Zhang C., Zhao M., Zong R., Zhang L., Shi L., Alfano R. R. Optical biopsy identification and grading of gliomas using label-free visible resonance Raman spectroscopy, J. of Biomedical Optics, 24(9), 095001, 2019.

31.  Liu C., Wu B., Sordillo L., Boydston-White S., Sriramoju V., Zhang C., Beckman H., Zhang L., Pei Z., Shi L., Alfano R. R. "A pilot study for distinguishing basal cell carcinoma from normal human skin tissues using visible resonance Raman spectroscopy". J Cancer Metastasis Treat; 5:4, 2019.

2018

30.  Zhou Y, Liu C, Wu B, Zhang C, Yu X, Cheng G, Chen H, Li S, Liang Q, Zhang M, Zhu K, Shi L, and Alfano R. R. "Molecular biomarkers characterization for human brain glioma grading using visible resonance Raman spectroscopy". APL Photonics 3, 120802, 2018.

29.  Shi L*, Zheng C*, Shen Y, Chen Z, Silveira E, Zhang L, Wei M, Liu C, De Sena-Tomas C, Targoff K, Min W. “Optical imaging of metabolic dynamics in animals”. Nature Communications, 9, 2995, 2018.

28.  Shi L, Shen Y, and Min W. “Visualizing protein synthesis in mice with in vivo labeling of deuterated amino acids using vibrational imaging”. APL Photonics 3, 092401, 2018.

27.  Long R, Zhang L, Shi L, Shen Y, Hu F, Zeng C. and Min W. “Two-color vibrational imaging of glucose metabolism by stimulated Raman scattering”. Chemical Communications 152-155, 2018.

26.  Mamani S, Shi L, Ahmed T, Karnik R, Rodríguez‐Contreras A, Nolan D. and Alfano R. R.  “Transmission of classically entangled beams through mouse brain tissue”. J. Biophotonics. 11(12):e201800096, 2018.

25.  Lu L, Shi L, Secor J, Alfano R. R. "Resonance Raman scattering of β-carotene solution excited by visible laser beams into second singlet state". J. Photochem. Photobiol. B 179:18-22, 2018.

2017

24.  Shen Y, Zhao Z, Zhang L, Shi L, Shahriar S, Chan R, Paolo G, Min W. “Metabolic activity induces membrane phase separation in endoplasmic reticulum”. PNAS 114(51):13394-13399, 2017.

23.  Sordillo DC, Sordillo LA, Sordillo PP, Shi L, Alfano RR. "Short wavelength infrared optical windows for evaluation of benign and malignant tissues". J. Biomed. Opt. 22(4):45002, 2017.

22.  Shi L**, Lindwasser L, Wang W, Rodríguez-Contreras A, and Alfano RR. “Propagation of Gaussian and Laguerre Gaussian vortex beams through mouse brain tissue”. J. Biophotonics 10(12): 1756-1760, 2017.

21.  Shi L, Lu L, Harvey G, Harvey T, Rodríguez-Contreras A, and Alfano RR. “Label-free fluorescence spectroscopy for detecting key biomolecules in brain tissue from a mouse model of Alzheimer’s disease”. Scientific Reports 7:2599, 2017.

20.  Das B*, Shi L*, Budansky Y, Rodríguez-Contreras A, and Alfano RR. “Alzheimer mouse brain tissue measured by time resolved fluorescence spectroscopy using single- and multi-photon excitation of label free native molecules”. J. Biophotonics 11(1), 2017. (co-first author).

2016

19.  Shi L, Galvez E, and Alfano R. R. “Photon entanglement through brain tissue”. Scientific Reports 6:37714, 2016.

18.  Liu C, Boydston-White S, Weisberg A, Wang W, Sordillo L, Perotte A, Tomaselli V, Sordillo P, Pei Z, Shi L, and Alfano RR. “Vulnerable atherosclerotic plaque detection by resonance Raman spectroscopy”, J. Biomed. Opt. 21 (12):127006, 2016.

17.  Alfano RR, Milione G, Galvez E. J., Shi L. “Optical sources: A laser for complex spatial modes”. Nature Photonics 10 (5): 286-288, 2016.

16.  Wang W, Gozali R, Shi L, and Alfano R. R. “Deep transmission of Laguerre-Gaussian vortex beams through turbid scattering media”. Opt. Lett. 41(9): 2069-72, 2016.

15.  Shi L**, Shumyatsky P, Rodríguez-Contreras A, Alfano R. R. “Terahertz spectra ofbrain tissue from a mouse model of Alzheimer disease”. J. Biomed. Opt. 21(1):015014-1, 2016.

14.  Shi L**, Sordillo LA, Rodríguez-Contreras A, Alfano R. R. “Transmission in near-infrared optical windows for deep brain imaging”. J. Biophotonics 9(1–2):38–43, 2016.

2014

13.  Shi L**, Rodriguez-Contreras A, Alfano R. R. “Gaussian beam in two photon fluorescence imaging of rat brain microvessel”. J. Biomed. Opt. 19(12):126006, 2014.

12.  Shi L, Palacio P, Badami J, Shin D, Zeng M, Cardoso L, Tu R, Fu B. M. “Quantification of transient increase of the blood-brain barrier permeability to macromolecules by optimized focused ultrasound combined with microbubbles”. Int. J. Nanomedicine. 9(1): 4437-48, 2014.

11.  Shi L, Zeng M, Fu BM. “Temporal effects of vascular endothelial growth factor and 3,5-cyclic monophosphate on blood–brain barrier solute permeability in vivo”. J. Neurosci. Res. 92(12):1678-89, 2014.

10.  Shi L, Rodriguez-Contreras A, Budansky Y, Pu Y, Nguyen T, Alfano R. R. “Deep two-photon microscopic imaging through brain tissue using the second singlet state from fluorescent agent chlorophyll α in spinach leaf”. J. Biomed. Opt. 19(6):066009, 2014.

9.   Shi L. Book review of “Diagnostic Endoscopy”. J. Biomed. Opt. 19(4):049902-1. 2014.

8.   Shi L, Zeng M, Sun Y, Fu B. M. “Quantification of blood-brain barrier solute permeability and brain transport by multiphoton microscopy”. J. Biomech. Eng. 136: 031005, 2014.

7.   Rodríguez-Contreras A, Shi L, Fu B. M. “A method to make a craniotomy on the ventral skull of neonate rodents”. J. Vis. Exp. (87), e51350, 2014.

6.   Islam SMZ, Gayen T, Tint N, Shi L, Seredych M, Bandosz T. J., and Alfano R. R. “The effects of fabrication temperature on current-voltage characteristics and energy efficiencies of quantum dot sensitized ZnOH-GO hybrid solar cells”. J. Appl. Phys. 116, 173102, 2014.

5.   Islam SMZ, Gayen T, Tint N, Shi L, Seredych M, Bandosz T. J., Alfano R. R. “Hybrid solar cells of micro/meso-porous Zn(OH)2 and its graphite composites sensitized by CdSe quantum dots”. J. Photon. Energy. 4 (1):043098, 2014.

2013

4.   Pu Y, Shi L, Pratavieira S, Alfano R. R. “Two-Photon excitation microscopy using the second singlet state of fluorescent agents within the tissue optical window”. J. Appl. Phys. 114(15):153102-4, 2013.

3.   Islam SMZ, Gayen T, Seredych M, Mabayoye O, Shi L, Bandosz TJ, and Alfano R. R. “Band gap energies of solar micro/meso-porous composites of zinc (hydr)oxide with graphite oxides”. J. Appl. Phys. 114 (4): 043522 - 6, 2013.

2.   Islam SMZ, Gayen T, Das B, Shi L, Seredych M, Moussawi A, Bandosz TJ, Alfano R. R. “Time resolved fluorescence of Zn(OH)2 and it composite with graphite Oxide”. Opt. Lett. 38(13): 2227- 2229, 2013.

1.   Islam SMZ, Gayen T, Moussawi A, Shi L, Seredych M, Bandosz TJ, Alfano R. R. “Structural and optical characterization of Zn(OH)2 and its composites with graphite oxides”. Opt. Lett. 38(6): 962- 964, 2013.

Patents

14.  Shi L., Li Y., Hao N., "Lipid Composition and Uses Thereof" U.S. Provisional Application Serial No. _63/637,565_ filed on April 23, 2024

13. Shi L., Li Y., Hao N., "Yeast Derived Lipids for Gut Health and Lifespan", U.S. Provisional Application Serial No. _63/572,647_ filed on April 1, 2024

12.Shi L., Jang H., "super-resolution stimulated raman scattering microscopy with adam optimization-based pointillism deconvolution (a-pod)" US Patent App. 18/485,043

11. Shi L., Zhang W., "Multi-molecular hyperspectral prm-srs imaging", Publication date 2024/10/15 Patent office US Application number 18484984

10. Shi L., Min W. “System, method and computer-accessible medium for use of heavy water as a probe for imaging metabolic activities”. Awarded US Patent number: US 12062422

9. Alfano RR, Mamani S., Shi L.,  "Method for imaging biological tissue using polarized majorana vector and complex vortex photons from laser and supercontinuum light sources", Awarded patent NO. US11614398 B2, USA, 03 28 2023.

8. Alfano RR, Shi L, Wu B, “Compact optical virus detection analyzer of nano-and micro-size bio particles using light scattering and fluorescence”, US Patent App. 17/503,086 2.      

7. Alfano RR, Mazhar SFB, Sharonov M, Shi L, “Table-top utra supercontinuum and higher harmonic generation source for microscopy”,. Awarded US Patent NO. 11817669, Nov. 14, 2023

6. Alfano R.R., Shi L. “Supercontinuum microscope for resonance and non-resonance enhanced linear and nonlinear time resolved microscope for tissue and materials”.  Awarded U.S. Patent NO. US10962751B2, 3/30/2021

5. Alfano R.R., Shi L. “Resonant Stimulated Raman Scattering Microscope”.  Awarded U.S. Patent NO. 10281331 , May 7 2019

4. Alfano R.R., Yang P., Shi L., Pratavieira S.  “Method of deep tissue imaging using multi-photon excitation of a fluorophore”. Awarded patent number 10420471. 09/04/2019

3. Alfano R.R., Shi L., Budansky Y. “Continuous Diode Laser Stimulated Raman Gain/Loss Vibrational Microscope”. Awarded patent number 10433731, 10/08/2019

2. Alfano R.R., Yang P., Shi L., Pratavieira S. “Method of deep tissue imaging using multi-photon excitation of a fluorophore”. Awarded Patent Number: US10420471B2 9/24/2019

1. Alfano R.R., Laura Sordillo, Yang Pu, Shi L. “Deep optical imaging of tissue with less scattering in the second, third and fourth NIR spectral windows using supercontinuum and other laser coherent light sources” Awarded patent Number: 10123705 Grant Date: 11/13/2018

Books and book chapters

UCSD:

6) Villazon, J.I., Shi, L. (2024). Advances in Biomedical Imaging Modalities for Cancer Research and Diagnostics. In: Interdisciplinary Cancer Research. Springer, Cham. https://doi.org/10.1007/16833_2024_355 

5) A Rodríguez-Contreras, L Shi, RR Alfano, Effects of tryptophan metabolism on the brain: From early development to Alzheimer's disease. Biophotonics, Tryptophan and Disease, 107-114

4) Wei W., Wang X., Li Y. , Cheng Y. , Fung A.A. Yang X., Wu J.Y., Shi L.**, Optical Imaging of Drug Delivery Across the Blood Brain Barrier, Progress in Optics, Elsevier, 2021 (chapter)

3) Li Y., Shi L.**, “Isotope-Probed SRS Imaging of Metabolic Dynamics in Living Organisms” , Ji-Xin Cheng, Wei Min, Yasuyuki Ozeki, Dario Polli (co-editors), Stimulated Raman Scattering Microscopy, Elsevier, 2021 (chapter)

Before UCSD:

2) Alfano R. R., Shi L. (Editors) “Neurophotonics and Biomedical Spectroscopy” (1st Ed.). Elsevier Publishing, 2018. ISBN-13: 978-0323480673. (Book)

1) Shi L, Alfano R. R. (Editors) “Deep Imaging in Tissue and biomedical materials using Linear and Non-linear Optics” (1st Ed.). Pan Stanford Publishing, 2017. ISBN 9789814745888. (Book)