Laboratory of Optical Bioimaging and Spectroscopy

Our goal is to develop and apply new ultrafast laser scanning optical imaging and spectroscopic technologies, such as stimulated Raman scattering (SRS), second harmonic generation (SHG), and multiphoton fluorescence (MPF) microscopy for visualizing metabolic dynamics in living organisms in situ with subcellular resolution.

We are applying bioorthogonal labelling SRS imaging techniques and MPF for directly visualizing complex molecular events in brain, cancer, and metabolic diseases, which offering powerful tools potentially for disease detection, diagnosis and treatment, as well as for mechanistic understanding of scientific fundamentals in neurodegenerative diseases, cancer, drug delivery, development, and aging processes.

Newly synthesized proteins, lipids, and DNA in a dividing cell.

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Recent Articles

Spectral Tracing of Isotope Deuterium for Imaging Glucose Metabolism

Volumetric Chemical Imaging by Clearing-enhanced Stimulated Raman Scattering Microscopy

Optical Imaging of Metabolic Dynamics in Animals