Molecular Metabolic Nanoscopy & Spectroscopy
Mapping Molecular Metabolic Activities at Sub-cellular Resolution for Studying Aging and Diseases
"Our goal is to develop and apply new ultrafast laser scanning multimodal imaging and spectroscopic technologies, such as stimulated Raman scattering (SRS), DO-SRS, second harmonic generation (SHG), Fluorescence Lifetime Imaigng (FLIM), and multiphoton fluorescence (MPF) microscopy, for visualizing molecular composition and metabolic dynamics in situ at subcellular resolution to study aging and diseases.
"Our goal is to develop and apply new ultrafast laser scanning multimodal imaging and spectroscopic technologies, such as stimulated Raman scattering (SRS), DO-SRS, second harmonic generation (SHG), Fluorescence Lifetime Imaigng (FLIM), and multiphoton fluorescence (MPF) microscopy, for visualizing molecular composition and metabolic dynamics in situ at subcellular resolution to study aging and diseases.
We discovered "Golden Window" (from 1550nm to 1870nm) wavelength for deep optical tissue imaging (Shi et al., 2016), and we have been developing and applying bioorthogonal imaging of complex molecular events and cellular machinery in living organisms during aging and disease progression, offering powerful tools potentially for diagnosis, and assessing therapeutic efficacy/resistance, as well as for mechanistic understanding of scientific fundamentals in neurodegenerative diseases, cancer, drug discovery, and aging processes."
We discovered "Golden Window" (from 1550nm to 1870nm) wavelength for deep optical tissue imaging (Shi et al., 2016), and we have been developing and applying bioorthogonal imaging of complex molecular events and cellular machinery in living organisms during aging and disease progression, offering powerful tools potentially for diagnosis, and assessing therapeutic efficacy/resistance, as well as for mechanistic understanding of scientific fundamentals in neurodegenerative diseases, cancer, drug discovery, and aging processes."
Newly synthesized proteins, lipids, and DNA in a dividing cell.
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