"Prof. Lingyan Shi and her team are developing and applying new ultrafast laser scanning multimodal imaging and spectroscopic technologies, such as stimulated Raman scattering (SRS), DO-SRS, second harmonic generation (SHG), Fluorescence Lifetime Imaigng (FLIM), and multiphoton fluorescence (MPF) microscopy, for visualizing molecular events and metabolic dynamics in situ at subcellular resolution for studying aging and diseases. 

We discovered "Golden Window" (from 1550nm to 1870nm) wavelength for deep optical tissue imaging (Shi et al., 2016), and established A-POD (Jang et al., 2023) and PRM (Zhang et al., 2024) enhanced super resolution multi-molecular imaging platform. We have been developing bioorthogonal Raman scattering based SRS imaging methods for dissecting complex cellular machinery in living organisms during aging processes and disease progression, offering powerful tools potentially for diagnosis, assessing therapeutic efficacy/resistance, as well as for mechanistic understanding of scientific fundamentals in neurodegenerative diseases, cancer, drug discovery, and aging processes."

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